Apollo-taking the lead in telomere protection

Mol Cell. 2010 Aug 27;39(4):489-91. doi: 10.1016/j.molcel.2010.08.018.


The single-stranded overhangs at the ends of telomeres are thought to be critical for telomere maintenance, but how they are generated has been largely unclear. Two studies (one in this issue of Molecular Cell, Wu et al., 2010) have now implicated the Apollo nuclease in maintaining the overhang specifically at those telomeres generated by leading-strand DNA synthesis.

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