Survival and prognostic factors in malignant pleural mesothelioma: a retrospective study of 314 patients in the west part of Japan

Jpn J Clin Oncol. 2011 Jan;41(1):32-9. doi: 10.1093/jjco/hyq159. Epub 2010 Aug 26.


Objective: The objective in our study was to examine baseline and other characteristics associated with survival in patients with malignant pleural mesothelioma in Japan.

Methods: Three hundred and fourteen patients with an adjudicated diagnosis of mesothelioma were examined. Survival was evaluated by the Kaplan-Meier method with the log-rank test. The Cox model was used to estimate the hazard ratio for the possible prognostic factors.

Results: Of 314 patients, 223 (71%) died and only 40 (13%) were still alive at the end of the observation period starting from the day of diagnosis, while 51 (16%) were transferred to other hospitals or had the last health service contact before the end of the study period yielding the median survival of 308 days. In the multivariate analysis, age older than 70 years (hazard ratio = 2.17; 95% confidence interval, 1.36-3.46), non-epithelioid type (hazard ratio = 1.58; 95% confidence interval, 1.15-2.18), poor performance status (hazard ratio = 3.22; 95% confidence interval, 1.19-8.74), high white blood cell count (hazard ratio = 1.49; 95% confidence interval, 0.99-2.26) and high C-reactive protein level (hazard ratio = 1.80; 95% confidence interval, 1.06-3.06) were negatively associated with survival, after adjustment for other factors.

Conclusions: Some baseline conditions including old age, poor performance status, non-epithelioid type, high white blood cell count and high C-reactive protein level were determinants of poor survival of patients with malignant mesothelioma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / blood*
  • C-Reactive Protein / metabolism
  • Female
  • Humans
  • Japan / epidemiology
  • Kaplan-Meier Estimate
  • Leukocyte Count
  • Male
  • Mesothelioma / blood
  • Mesothelioma / mortality*
  • Mesothelioma / pathology
  • Middle Aged
  • Multivariate Analysis
  • Odds Ratio
  • Pleural Neoplasms / blood
  • Pleural Neoplasms / mortality*
  • Pleural Neoplasms / pathology
  • Prognosis
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Factors


  • Biomarkers, Tumor
  • C-Reactive Protein