Serum uric acid predicts progression of subclinical coronary atherosclerosis in individuals without renal disease

Diabetes Care. 2010 Nov;33(11):2471-3. doi: 10.2337/dc10-1007. Epub 2010 Aug 26.


Objective: To examine uric acid (UA) as a possible predictor of the progression of coronary artery calcification (CAC) using data from the prospective Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study.

Research design and methods: CAC was measured by electron beam tomography at the baseline and at a follow-up 6.0±0.5 years later. The study population included 443 participants with type 1 diabetes and 526 control subjects who were free of diagnosed coronary artery disease at baseline. The presence of renal disease was defined by the presence of albuminuria and/or low glomerular filtration rate.

Results: In subjects without renal disease, serum UA predicted CAC progression (odds ratio 1.30 [95% CI 1.07-1.58], P=0.007) independent of conventional cardiovascular risk factors including diabetes and the presence of metabolic syndrome.

Conclusions: Serum UA levels predict the progression of coronary atherosclerosis and may be useful in identifying who is at risk for vascular disease in the absence of significant chronic kidney disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / pathology
  • Disease Progression
  • Female
  • Humans
  • Kidney Diseases*
  • Male
  • Middle Aged
  • Uric Acid / blood*


  • Uric Acid