Growth of melanoma brain tumors monitored by photoacoustic microscopy

J Biomed Opt. Jul-Aug 2010;15(4):040510. doi: 10.1117/1.3478309.

Abstract

Melanoma is a primary malignancy that is known to metastasize to the brain and often causes death. The ability to image the growth of brain melanoma in vivo can provide new insights into its evolution and response to therapies. In our study, we use a reflection mode photoacoustic microscopy (PAM) system to detect the growth of melanoma brain tumor in a small animal model. The melanoma tumor cells are implanted in the brain of a mouse at the beginning of the test. Then, PAM is used to scan the region of implantation in the mouse brain, and the growth of the melanoma is monitored until the death of the animal. It is demonstrated that PAM is capable of detecting and monitoring the brain melanoma growth noninvasively in vivo.

Publication types

  • Letter

MeSH terms

  • Animals
  • Brain Neoplasms / pathology*
  • Cell Line, Tumor
  • Cell Proliferation
  • Equipment Design
  • Equipment Failure Analysis
  • Melanoma / pathology*
  • Mice
  • Mice, Inbred BALB C
  • Microscopy, Acoustic / instrumentation*
  • Microscopy, Acoustic / methods*
  • Neoplasm Invasiveness
  • Reproducibility of Results
  • Sensitivity and Specificity