Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia

Mol Cancer. 2010 Aug 27;9:226. doi: 10.1186/1476-4598-9-226.

Abstract

PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid signalling has been proposed. Sequence homology and structural predictions suggest that PRAME is related to the leucine-rich repeat (LRR) family of proteins, which have diverse functions. Here we review the current knowledge of the structure/function of PRAME and its relevance in leukaemia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Antigens, Neoplasm / chemistry
  • Antigens, Neoplasm / genetics
  • Antigens, Neoplasm / metabolism
  • Antigens, Neoplasm / physiology*
  • Cell Differentiation / physiology
  • Cell Proliferation
  • Expressed Sequence Tags
  • Humans
  • Leukemia / physiopathology*
  • Molecular Sequence Data
  • Multigene Family
  • Neoplasm, Residual
  • Receptors, Retinoic Acid / metabolism
  • Signal Transduction
  • Subcellular Fractions / metabolism

Substances

  • Antigens, Neoplasm
  • PRAME protein, human
  • Receptors, Retinoic Acid