Abstract
PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid signalling has been proposed. Sequence homology and structural predictions suggest that PRAME is related to the leucine-rich repeat (LRR) family of proteins, which have diverse functions. Here we review the current knowledge of the structure/function of PRAME and its relevance in leukaemia.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Antigens, Neoplasm / chemistry
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Antigens, Neoplasm / genetics
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Antigens, Neoplasm / metabolism
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Antigens, Neoplasm / physiology*
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Cell Differentiation / physiology
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Cell Proliferation
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Expressed Sequence Tags
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Humans
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Leukemia / physiopathology*
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Molecular Sequence Data
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Multigene Family
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Neoplasm, Residual
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Receptors, Retinoic Acid / metabolism
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Signal Transduction
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Subcellular Fractions / metabolism
Substances
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Antigens, Neoplasm
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PRAME protein, human
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Receptors, Retinoic Acid