Prevalence of Non-Motor Dysfunction Among Parkinson's Disease Patients From a Tertiary Referral Center in Mexico City

Clin Neurol Neurosurg. 2010 Dec;112(10):883-5. doi: 10.1016/j.clineuro.2010.07.021. Epub 2010 Aug 25.


Data on the frequency of non-motor symptoms among patients with Parkinson's disease (PD) in Mexico has not been reported.

Objective: To study the prevalence of these symptoms in a sample of Mexican PD patients attending a referral neurologic center using the Non Motor Symptoms Questionnaire (NMSQuest) and the Non Motor Symtpoms Scale (NMSS).

Methods: One-hundred consecutive PD patients, of all ages and disease severity were included in a cross-sectional design study. The NMSQuest and NMSS were applied during the "on" state.

Results: Sample had a mean age of 64.5±10.9 years and disease duration of 6.6±4.8 years. Total NMSQuest median score was 10 and the mean NMSS score was 69.3±56.7. Positive answers classified by domain were as follows: gastrointestinal symptoms 30%, urinary symptoms 60%, memory/attention/apathy 39%, hallucinations/delusions 16%, depression/anxiety 55%, sexual dysfunction 30%, cardiovascular symptoms 35%, sleep disorders 40% and miscellany 27%.

Conclusion: The prevalence of non-motor symptoms among mexican patients with PD is similar to other countries. Mood, cognitive and perceptual symptoms seems to be more severe in our population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antiparkinson Agents / therapeutic use
  • Cross-Sectional Studies
  • Dopamine Agonists / therapeutic use
  • Female
  • Humans
  • Levodopa / therapeutic use
  • Male
  • Mexico / epidemiology
  • Middle Aged
  • Parkinson Disease / complications*
  • Parkinson Disease / epidemiology*
  • Parkinson Disease / physiopathology
  • Surveys and Questionnaires


  • Antiparkinson Agents
  • Dopamine Agonists
  • Levodopa