Intracytoplasmic sperm injection outcome versus intracytoplasmic morphologically selected sperm injection outcome: a meta-analysis

Reprod Biomed Online. 2010 Oct;21(4):450-5. doi: 10.1016/j.rbmo.2010.05.017. Epub 2010 Jun 19.


The development of a modified intracytoplasmic sperm injection (ICSI), called intracytoplasmic morphologically selected sperm injection (IMSI), demonstrated that a profound morphological investigation of the spermatozoon, under the magnification of 6600 x, enables outcome improvement. The aim of this study was to compare ICSI outcome with IMSI outcome. The meta-analysis results demonstrated no significant difference in fertilization rate between ICSI and IMSI groups. However, a significantly improved implantation (odds ratio (OR) 2.72; 95% confidence interval (CI) 1.50-4.95) and pregnancy rate (OR 3.12; 95% CI 1.55-6.26) was observed in IMSI cycles. Moreover, the results showed a significantly decreased miscarriage rate (OR 0.42; 95% CI 0.23-0.78) in IMSI cycles as compared with ICSI cycles. This is the first meta-analysis of published data to evaluate the potential benefits of IMSI. The pooled data of IMSI cycles demonstrate a statistically significant improvement in implantation and pregnancy rates and a statistically significant reduction in miscarriage rates. However, more randomized controlled trials are needed to confirm these results.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Abortion, Spontaneous / epidemiology
  • Adult
  • Embryo Implantation
  • Female
  • Fertilization in Vitro / methods
  • Humans
  • Male
  • Pregnancy
  • Pregnancy Rate
  • Sperm Injections, Intracytoplasmic / methods*
  • Spermatozoa / ultrastructure*
  • Treatment Outcome