Post-licensure comparison of the safety profile of diphtheria/tetanus/whole cell pertussis/haemophilus influenza type b vaccine and a 5-in-1 diphtheria/tetanus/acellular pertussis/haemophilus influenza type b/polio vaccine in the United Kingdom

Vaccine. 2010 Oct 18;28(44):7215-20. doi: 10.1016/j.vaccine.2010.08.062. Epub 2010 Aug 26.


General practitioner consultation data were used to compare the reactogenicity in infants of a 5-in-1 acellular pertussis vaccine (DTaP(5)/Hib/IPV) introduced in the United Kingdom in 2004 to the 4-in-1 whole cell-pertussis vaccine (DTwP/Hib) that it replaced. For each vaccine the incidence in the week following vaccination was compared to other periods to obtain a relative incidence. A lower relative incidence of crying, fever and local reactions was seen with DTaP(5)/Hib/IPV than DTwP/Hib. Although there were no other significant differences between vaccines the relative incidence was significantly above one on the day of vaccination for convulsions following DTwP/Hib and for apnoea/collapse following DTaP(5)/Hib/IPV.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Diphtheria-Tetanus-Pertussis Vaccine / adverse effects*
  • General Practitioners
  • Haemophilus Vaccines / adverse effects*
  • Humans
  • Infant
  • Poliovirus Vaccine, Inactivated / adverse effects*
  • Product Surveillance, Postmarketing*
  • United Kingdom
  • Vaccines, Conjugate / adverse effects


  • Diphtheria-Tetanus-Pertussis Vaccine
  • Haemophilus Vaccines
  • Poliovirus Vaccine, Inactivated
  • Vaccines, Conjugate
  • diphtheria-tetanus-five component acellular pertussis-inactivated poliomyelitis -Haemophilus influenzae type b conjugate vaccine