Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Dec 15;229(1-2):157-68.
doi: 10.1016/j.jneuroim.2010.07.028.

Increased Intramuscular Nerve Branching and Inhibition of Programmed Cell Death of Chick Embryo Motoneurons by Immunoglobulins From Patients With Motoneuron Disease

Affiliations

Increased Intramuscular Nerve Branching and Inhibition of Programmed Cell Death of Chick Embryo Motoneurons by Immunoglobulins From Patients With Motoneuron Disease

Sara Hernández et al. J Neuroimmunol. .

Abstract

Massive programmed cell death (PCD) of developing chick embryo motoneurons (MNs) occurs in a well defined temporal and spatial sequence between embryonic day (E) 6 and E10. We have found that, when administered in ovo, either circulating immunoglobulins G (IgGs) or cerebrospinal fluid from patients with MN disease can rescue a significant number of chick embryo MNs from normally occurring PCD. An increase of branching of intramuscular nerves was also observed that may account for the rescuing effects of pathologic IgGs. Proteomic analysis and further analysis by ELISA indicated that these effects may be mediated by the interaction of circulating human immunoglobulins with proteins of the semaphorin family.

Similar articles

See all similar articles

Cited by 1 article

Publication types

MeSH terms

LinkOut - more resources

Feedback