The V-ATPase: small cargo, large effects

Curr Opin Plant Biol. 2010 Dec;13(6):724-30. doi: 10.1016/j.pbi.2010.07.003. Epub 2010 Aug 26.


About 30 years ago seminal reports of anion-sensitive proton-pumping activity associated with microsomal membranes initiated research on the plant vacuolar-type H(+)-ATPase (V-ATPase, VHA). Since, it has been firmly established that these complex molecular machines are essential for what can be defined as cellular logistics. In a eukaryotic cell, the flow of goods between compartments is achieved either by protein-mediated membrane transport or via vesicular trafficking. Over the past years, it has become increasingly clear that V-ATPases do not only energize secondary active transport but are also important regulators of membrane trafficking.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biological Transport
  • Cell Membrane / metabolism
  • Plants / enzymology*
  • Plants / metabolism*
  • Vacuolar Proton-Translocating ATPases / genetics
  • Vacuolar Proton-Translocating ATPases / metabolism*


  • Vacuolar Proton-Translocating ATPases