The concave iris in pigment dispersion syndrome

Ophthalmology. 2011 Jan;118(1):66-70. doi: 10.1016/j.ophtha.2010.04.039.


Objective: To visualize the changes of the iris contour in patients with pigment dispersion syndrome after blinking, accommodation, and pharmacologic miosis using anterior segment optical coherence tomography.

Design: Observational case series.

Participants: A total of 33 eyes of 20 patients with pigment dispersion syndrome.

Methods: Each eye was imaged along the horizontal 0- to 180-degree meridian using the Visante Anterior Segment Imaging System (Carl Zeiss Meditec, Dublin, CA). Scans were performed at baseline and after focusing on an internal fixation target for 5 minutes, forced blinking, accommodation, and pharmacologic miosis with pilocarpine 2%.

Main outcome measures: Quantitative analysis of the changes in the iris configuration.

Results: After 5 minutes of continual fixation, the iris became planar with the mean ± standard deviation curvature decreasing from 214 ± 74 μm to 67 ± 76 μm (P < 0.05). The iris remained planar in all patients with pigment dispersion syndrome after forced blinking, but the iris concavity recovered to 227 ± 113 μm (P = 0.34) and 238 ± 119 μm (P = 0.19) with the -3.0 and -6.0 diopter lenses, respectively. Pilocarpine-induced miosis caused the iris to assume a planar configuration in all subjects.

Conclusions: This study shows that the iris in pigment dispersion syndrome assumes a planar configuration when fixating and that the concavity of the iris surface is not restored by blinking. Accommodation restored the iris concavity, suggesting that the posterior curvature of the iris in pigment dispersion syndrome is induced and probably maintained, at least in part, by accommodation.

MeSH terms

  • Accommodation, Ocular / physiology*
  • Adolescent
  • Adult
  • Aged
  • Blinking / physiology
  • Exfoliation Syndrome / physiopathology*
  • Female
  • Humans
  • Intraocular Pressure / physiology
  • Iris / physiopathology*
  • Male
  • Middle Aged
  • Miotics / administration & dosage
  • Pilocarpine / administration & dosage
  • Prospective Studies
  • Pupil / drug effects
  • Tomography, Optical Coherence
  • Young Adult


  • Miotics
  • Pilocarpine