The effects of uncoupling protein 1 and beta3-adrenergic receptor gene polymorphisms on weight loss and lipid profiles in obese women

Int J Vitam Nutr Res. 2010 Apr;80(2):87-96. doi: 10.1024/0300-9831/a000009.


The purpose of this study was to investigate whether the genetic polymorphisms of the uncoupling protein 1 (UCP1) and beta 3 adrenergic receptor (beta3-AR) were associated with differences in weight loss and lipid profiles in obese premenopausal women exposed to low-calorie meal replacements over a period of six weeks. Forty women between the ages of 20 and 35 were randomly divided into two groups, each of which consumed one of two low-calorie meal replacements containing either white rice or mixed rice. Although body weight, body mass index (BMI), blood glucose concentration, triglycerides, total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) were not significantly different by the UCP1 genotype in the white rice group, there were significant differences in body weight (p = 0.041), BMI (p = 0.027), and blood glucose concentration (p = 0.047) between carriers and non-carriers of the G allele in the mixed rice group after the six-week meal replacement intervention. The beta3-AR polymorphism showed no apparent affect on these parameters. Dietary fiber affects weight gain since it is closely related with absorption of nutrients. As a result, the AA type UCP1 genotype produced significant weight loss in the mixed rice group, but not in the white rice group.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Blood Glucose
  • Body Mass Index
  • Body Weight
  • Diet, Reducing / methods
  • Dietary Fiber
  • Female
  • Humans
  • Ion Channels / blood
  • Ion Channels / genetics*
  • Lipids / blood*
  • Lipids / genetics
  • Mitochondrial Proteins / blood
  • Mitochondrial Proteins / genetics*
  • Obesity / blood*
  • Obesity / genetics
  • Oryza
  • Polymorphism, Genetic / genetics*
  • Receptors, Adrenergic, beta-3 / blood
  • Receptors, Adrenergic, beta-3 / genetics*
  • Uncoupling Protein 1
  • Weight Loss / genetics*
  • Young Adult


  • Blood Glucose
  • Dietary Fiber
  • Ion Channels
  • Lipids
  • Mitochondrial Proteins
  • Receptors, Adrenergic, beta-3
  • UCP1 protein, human
  • Uncoupling Protein 1