Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophore

J Med Chem. 2010 Nov 25;53(22):7902-17. doi: 10.1021/jm100762r. Epub 2010 Aug 30.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / pharmacology
  • Anti-HIV Agents / therapeutic use
  • Cardiovascular Agents / chemistry
  • Cardiovascular Agents / pharmacology
  • Cardiovascular Agents / therapeutic use
  • Cathepsins / antagonists & inhibitors
  • Central Nervous System Agents / chemistry
  • Central Nervous System Agents / pharmacology
  • Central Nervous System Agents / therapeutic use
  • Crystallography, X-Ray
  • Dipeptidyl-Peptidase IV Inhibitors / chemistry
  • Dipeptidyl-Peptidase IV Inhibitors / pharmacology
  • Dipeptidyl-Peptidase IV Inhibitors / therapeutic use
  • Drug Discovery
  • Humans
  • Models, Molecular
  • Molecular Structure
  • Nitriles / chemistry*
  • Nitriles / pharmacology
  • Nitriles / therapeutic use
  • Structure-Activity Relationship
  • Xanthine Oxidase / antagonists & inhibitors

Substances

  • Anti-HIV Agents
  • Cardiovascular Agents
  • Central Nervous System Agents
  • Dipeptidyl-Peptidase IV Inhibitors
  • Nitriles
  • Xanthine Oxidase
  • Cathepsins