Recent insights into the role of NF-kappaB in ovarian carcinogenesis

Genome Med. 2010 Aug 25;2(8):56. doi: 10.1186/gm177.


The NF-κBs are a family of ubiquitously expressed transcription factors that have been described to be responsible for the establishment of an inflammatory response. Studies in the past decade have also demonstrated this family's role in the initiation and progression of hematological and solid tumors. Recently, research has uncovered a specific role for NF-κBs in the development and maintenance of ovarian cancer.