Paraneoplastic Acanthosis Nigricans: The importance of exhaustive and repeated malignancy screening

Dermatol Online J. 2010 Aug 15;16(8):8.


Paraneoplastic acanthosis nigricans (P-AN) characteristically has a sudden onset, rapid progression, and extensive cutaneous involvement. The association between P-AN and internal malignancy is well established and the most common association is with adenocarcinoma of gastrointestinal origin. We present the case of an 81-year-old man with a 12-month history of anorexia, weight loss, and clinical evidence of extensive acanthosis nigricans. After exhaustive and repeated investigations a papillary thyroid carcinoma and a follicular adenoma were identified and he improved upon its resection. To our knowledge, P-AN in association with thyroid neoplasm has been reported on only one previous occasion.

Publication types

  • Case Reports

MeSH terms

  • Acanthosis Nigricans / complications
  • Acanthosis Nigricans / diagnosis*
  • Acanthosis Nigricans / pathology
  • Adenoma / diagnosis*
  • Adenoma / etiology
  • Adenoma / pathology
  • Aged, 80 and over
  • Carcinoma, Papillary / diagnosis*
  • Carcinoma, Papillary / etiology
  • Carcinoma, Papillary / pathology
  • Humans
  • Male
  • Paraneoplastic Syndromes / diagnosis*
  • Paraneoplastic Syndromes / etiology
  • Paraneoplastic Syndromes / pathology
  • Thyroid Neoplasms / diagnosis*
  • Thyroid Neoplasms / etiology
  • Thyroid Neoplasms / pathology
  • Treatment Outcome