Abstract
Current biosynthetic methods for producing proteins containing site-specifically incorporated unnatural amino acids are inefficient because the majority of the amino acid goes unused. Here we present a universal approach to improve the efficiency of such processes using condensed Escherichia coli cultures.
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acids / metabolism*
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Amino Acyl-tRNA Synthetases / metabolism
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Benzophenones / metabolism
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Escherichia coli / metabolism*
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Phenylalanine / analogs & derivatives
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Phenylalanine / metabolism
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Recombinant Proteins / biosynthesis*
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Recombinant Proteins / chemistry
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Ubiquitin / biosynthesis
Substances
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4-benzoylphenylalanine
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Amino Acids
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Benzophenones
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Recombinant Proteins
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Ubiquitin
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Phenylalanine
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Amino Acyl-tRNA Synthetases