Nonrotation is a part of the spectrum of anatomic anomalies comprising malrotation. Most cases of nonrotation are symptomatic and managed surgically with a Ladd's procedure. However, incidental discovery of asymptomatic patients has also been reported. In these cases, the role of surgery is debated. The authors describe a case of nonrotation in a young woman with constipation-predominant irritable bowel syndrome that caused symptoms associated with nonrotation. Medical management of her irritable bowel syndrome resulted in the resolution of all abdominal complaints and a Ladd's procedure was not recommended. The authors include a literature review of nonrotation with an emphasis on the treatment of asymptomatic disease.