Intraoperative hyperthermic intraperitoneal chemotherapy after cytoreductive surgery for peritoneal carcinomatosis in an experimental model

Br J Surg. 2010 Dec;97(12):1874-80. doi: 10.1002/bjs.7249. Epub 2010 Aug 30.


Background: The combination of cytoreductive surgery (CS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is the treatment of choice for selected patients with peritoneal carcinomatosis (PC) of colorectal origin. However, it remains to be proven whether the addition of HIPEC to CS is essential for the reported survival benefit.

Methods: Sixty WAG/Rij rats were inoculated intraperitoneally with the rat colonic carcinoma cell line CC-531. Animals were randomized into three treatment groups: CS alone, CS followed by HIPEC (mitomycin 15 mg/m(2) ) and CS followed by HIPEC (mitomycin 35 mg/m(2) ). Survival was the primary outcome parameter.

Results: The median survival of rats treated with CS alone was 43 days. Rats receiving HIPEC 15 mg/m(2) and HIPEC 35 mg/m(2) both had a significantly longer median survival of 75 days (P = 0·003) and 97 days (P < 0·001) respectively. Rats receiving HIPEC showed a significantly lower tumour load at autopsy compared with rats treated with CS alone.

Conclusion: A combination of CS and HIPEC results in longer survival than CS alone in rats with PC of colorectal origin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / therapeutic use*
  • Cell Line, Tumor
  • Colorectal Neoplasms*
  • Combined Modality Therapy / methods
  • Hyperthermia, Induced / methods*
  • Injections, Intraperitoneal
  • Male
  • Mitomycin / therapeutic use*
  • Neoplasm Transplantation
  • Peritoneal Neoplasms / secondary
  • Peritoneal Neoplasms / therapy*
  • Random Allocation
  • Rats


  • Antineoplastic Agents
  • Mitomycin