Management of neuropsychiatric symptoms in people with dementia

CNS Drugs. 2010 Sep;24(9):729-39. doi: 10.2165/11319240-000000000-00000.


Neuropsychiatric symptoms are frequent and troublesome in people with dementia and present a major treatment challenge for clinicians. Most good practice guidelines suggest non-pharmacological treatments as the first-line therapy and there is emerging evidence, including randomized controlled trials, that a variety of psychological and training interventions, including social interaction and person-centred care training, are effective. There is evidence from meta-analyses that some atypical antipsychotic drugs, specifically risperidone and aripiprazole, confer benefit in the treatment of aggression in people with Alzheimer's disease over a period of up to 12 weeks. However, these benefits have to be considered in the context of significant adverse events, including extrapyramidal symptoms, accelerated cognitive decline, stroke and death. In addition, the limited evidence available does not indicate ongoing treatment benefits over longer periods of therapy. The evidence is limited for other pharmacological treatment approaches, but the best evidence is probably for carbamazepine, memantine and citalopram. There is very limited evidence for any therapies in non-Alzheimer dementias. In conclusion, it is important in most situations to limit the use of antipsychotic medication to short-term treatment (up to 12 weeks) of severe neuropsychiatric symptoms to limit harm. Non-pharmacological therapies offer a viable and effective alternative in many situations. Adequately powered randomized controlled trials for the treatment of clinically significant agitation are urgently needed to explore alternative pharmacological therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aggression / drug effects*
  • Aggression / psychology
  • Central Nervous System Agents / administration & dosage
  • Central Nervous System Agents / adverse effects
  • Central Nervous System Agents / therapeutic use*
  • Complementary Therapies*
  • Dementia / physiopathology
  • Dementia / psychology
  • Dementia / therapy*
  • Drug Administration Schedule
  • Humans
  • Psychomotor Agitation / psychology
  • Psychomotor Agitation / therapy*


  • Central Nervous System Agents