Sensory neuropeptides are involved in cigarette smoke induced airway hyperreactivity in guinea-pig

Agents Actions Suppl. 1990;31:215-22. doi: 10.1007/978-3-0348-7379-6_27.

Abstract

Acute cigarette smoke exposure in anaesthetized guinea-pigs resulted in non-specific airway hyperreactivity associated with inflammatory cell influx within the lung. Sensory neuropeptides seem to be involved in the genesis of smoke induced airway hyperreactivity.

MeSH terms

  • Acetylcholine / pharmacology
  • Animals
  • Bronchoconstriction
  • Capsaicin / pharmacology
  • Dose-Response Relationship, Drug
  • Guinea Pigs
  • Histamine / pharmacology
  • Hydrocortisone / pharmacology
  • Male
  • Neuropeptides / physiology*
  • Plants, Toxic*
  • Respiratory Hypersensitivity / etiology*
  • Sensation / physiology*
  • Smoke / adverse effects*
  • Tobacco*
  • Vagotomy

Substances

  • Neuropeptides
  • Smoke
  • Histamine
  • Acetylcholine
  • Capsaicin
  • Hydrocortisone