Serum albumin and biomolecular oxidative damage of human atherosclerotic plaques

Abstract

Objectives: To investigate the association of serum albumin (SA) with oxidative damage of human atherosclerotic plaques and the severity of atherosclerosis.

Design and methods: Correlation of the levels of SA with those of lipid and protein oxidation of endarterectomy-removed carotid atherosclerotic plaques; SA and plaque oxidative biomarkers comparison between 2 groups of patients with different severity of atherosclerotic carotid stenosis, i.e. <90% (group I) or ≥90% (group II).

Results: SA was strongly inversely correlated with plaque oxidative damage; SA was lower and plaque oxidative damage higher in group II than group I.

Conclusions: Lowered SA is associated with oxidative damage of atherosclerotic plaques and the severity of atherosclerosis.