Activation of ERα is necessary for estradiol's anorexigenic effect in female rats

Horm Behav. 2010 Nov;58(5):872-7. doi: 10.1016/j.yhbeh.2010.08.012. Epub 2010 Aug 31.


While there is considerable evidence that the ovarian hormone estradiol reduces food intake in female rats, it is unclear which estrogen receptor (ER) subtype, ERα or ERβ, mediates this effect. While several studies have demonstrated that activation of ERα, but not ERβ, is sufficient to reduce food intake in ovariectomized (OVX) rats, there are limited data regarding which receptor subtype is necessary. Here we used the selective ERα and ERß antagonists, MPrP and PHTPP, respectively, to investigate this question. We found that antagonism of ERα, but not ERβ, prevented the decrease in food intake following acute administration of estradiol in OVX rats. In addition, antagonism of ERα prevented the estrous-related, phasic reduction in food intake that occurs in response to the rise in circulating levels of estradiol in cycling rats. We conclude that activation of ERα is necessary for the anorexigenic effects of exogenous and endogenous estradiol in female rats.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Anorexia / chemically induced*
  • Anorexia / metabolism
  • Appetite Depressants / pharmacology
  • Drug Evaluation, Preclinical
  • Eating / drug effects
  • Eating / physiology
  • Estradiol / pharmacology*
  • Estradiol / physiology
  • Estrogen Receptor alpha / agonists*
  • Estrogen Receptor alpha / metabolism
  • Estrogen Receptor alpha / physiology
  • Female
  • Ovariectomy
  • Piperidines / pharmacology
  • Pyrazoles / pharmacology
  • Pyrimidines / pharmacology
  • Rats
  • Rats, Long-Evans
  • Selective Estrogen Receptor Modulators / pharmacology


  • 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole
  • 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol
  • Appetite Depressants
  • Estrogen Receptor alpha
  • Piperidines
  • Pyrazoles
  • Pyrimidines
  • Selective Estrogen Receptor Modulators
  • Estradiol