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Review
. 2010 Jul;30(4):366-73.
doi: 10.1016/j.semnephrol.2010.06.003.

Hereditary interstitial kidney disease

Anthony J Bleyer  1 , P Suzanne Hart, Stanislav Kmoch
Affiliations
Review

Hereditary interstitial kidney disease

Anthony J Bleyer et al. Semin Nephrol. 2010 Jul.

Abstract

Autosomal-dominant interstitial kidney disease is characterized by slow progression of chronic kidney disease in patients with bland urinary sediment and no or low-grade proteinuria. There are at least three subtypes. Patients with mutations in the UMOD gene encoding uromodulin suffer from precocious gout in addition to chronic kidney failure. Diagnosis can be achieved through genetic analysis of the UMOD gene. Patients with mutations in the REN gene encoding renin suffer from anemia in childhood, hyperuricemia, mild hyperkalemia, and progressive kidney disease. Genetic analysis of the REN gene can be performed to diagnose affected individuals. There is a third form of inherited interstitial kidney disease for which the cause has not been found. These individuals suffer from chronic kidney disease with no other identified clinical signs. Linkage to chromosome 1 has been identified in a number of these families. Proper diagnosis is valuable not only to the affected individual but also to the entire family and can facilitate treatment, transplantation, and research efforts.

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Figures

Figure 1
Figure 1
Approach to the diagnosis of inherited interstitial kidney disease.
See this image and copyright information in PMC

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