[Vitamin K and fracture]

Clin Calcium. 2010 Sep;20(9):1334-40.
[Article in Japanese]


Vitamin K is well known for its role in the synthesis of a number of blood coagulation factors. Vitamin K is also an important factor for bone metabolism via gamma-carboxylation of vitamin K-dependent proteins such as osteocalcin, matrix Gla protein, and protein S. Recent studies suggest that there is potential vitamin K insufficiency in bone, even in sufficient vitamin K status for blood coagulation. In the present review, the studies concerning relationship between vitamin K status and fracture are reviewed.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Calcium-Binding Proteins / metabolism
  • Extracellular Matrix Proteins / metabolism
  • Female
  • Fractures, Bone / etiology*
  • Fractures, Bone / prevention & control*
  • Humans
  • Male
  • Matrix Gla Protein
  • Middle Aged
  • Osteocalcin / metabolism
  • Vitamin K / administration & dosage*
  • Vitamin K / physiology
  • Vitamin K Deficiency / complications
  • Young Adult


  • Calcium-Binding Proteins
  • Extracellular Matrix Proteins
  • Osteocalcin
  • Vitamin K