High incidence of mental retardation in Turner syndrome patients with ring chromosome X formation

J P Fryns; A Kleczkowska; H Van Den Berghe

High incidence of mental retardation in Turner syndrome patients with ring chromosome X formation

Genet Couns. 1990;1(2):161-5.

Authors

J P Fryns¹, A Kleczkowska, H Van Den Berghe

Affiliation

¹ Centre for Human Genetics, University of Leuven, Belgium.

PMID: 2080999

Abstract

In this report we describe and comment the high incidence of mental subnormality in a series of 21 Turner syndrome patients with ring chromosome X, diagnosed in Leuven in the period 1965-1989. In 7 of the 21 (one third) a varying degree of mental retardation, from borderline intelligence to severe mental retardation was found. In 4 of them (18.5%) mental retardation was moderate to severe.

MeSH terms

Adolescent
Adult
Child
Child Development
Diseases in Twins / genetics
Female
Follow-Up Studies
Humans
Infant, Newborn
Intellectual Disability / genetics*
Intelligence
Karyotyping
Longitudinal Studies
Ring Chromosomes*
Sex Chromosome Aberrations / genetics*
Turner Syndrome / genetics*
Twins, Monozygotic / genetics
X Chromosome*