The cytoplasmic fate of an mRNP is determined cotranscriptionally: exception or rule?

Genes Dev. 2010 Sep 1;24(17):1827-31. doi: 10.1101/gad.1972810.


She2p is an RNA-binding protein that recognizes a zipcode on specific mRNAs necessary for the assembly of a protein complex that localizes them to the yeast bud tip. In this issue of Genes & Development, Shen and colleagues (pp. 1914-1926) demonstrate that She2p associates with RNAPII globally, but then recognizes the nascent chain only if it contains a zipcode. This demonstrates yet another case where the mRNA's cytoplasmic fate is determined by the RNAPII complex.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Cell Differentiation
  • Cytoplasm / metabolism*
  • Drosophila / cytology
  • Drosophila / embryology
  • Protein Binding
  • Protein Biosynthesis
  • Protein Transport
  • RNA Polymerase II / metabolism
  • RNA Stability
  • RNA Transport*
  • Ribonucleoproteins / metabolism*
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / metabolism
  • Transcription, Genetic*


  • Ribonucleoproteins
  • messenger ribonucleoprotein
  • RNA Polymerase II