tRNA biology charges to the front

Genes Dev. 2010 Sep 1;24(17):1832-60. doi: 10.1101/gad.1956510.


tRNA biology has come of age, revealing an unprecedented level of understanding and many unexpected discoveries along the way. This review highlights new findings on the diverse pathways of tRNA maturation, and on the formation and function of a number of modifications. Topics of special focus include the regulation of tRNA biosynthesis, quality control tRNA turnover mechanisms, widespread tRNA cleavage pathways activated in response to stress and other growth conditions, emerging evidence of signaling pathways involving tRNA and cleavage fragments, and the sophisticated intracellular tRNA trafficking that occurs during and after biosynthesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Nucleolus / metabolism
  • Evolution, Molecular
  • Humans
  • Protein Processing, Post-Translational
  • RNA Splicing
  • RNA Stability
  • RNA Transport
  • RNA, Transfer* / biosynthesis
  • RNA, Transfer* / genetics
  • RNA, Transfer* / metabolism
  • Signal Transduction
  • Transcription, Genetic


  • RNA, Transfer