A look at autoimmunity and inflammation in the eye

J Clin Invest. 2010 Sep;120(9):3073-83. doi: 10.1172/JCI42440. Epub 2010 Sep 1.


Autoimmune and inflammatory uveitis are a group of potentially blinding intraocular inflammatory diseases that arise without a known infectious trigger and are often associated with immunological responses to unique retinal proteins. In the United States, about 10% of the cases of severe visual handicap are attributed to this group of disorders. As I discuss here, experimental models of ocular autoimmunity targeting retinal proteins have brought about a better understanding of the basic immunological mechanisms involved in the pathogenesis of uveitis and are serving as templates for the development of novel therapies.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmunity / immunology*
  • Disease Models, Animal
  • Eye / anatomy & histology
  • Eye / immunology*
  • Eye / pathology
  • Forecasting
  • Humans
  • Inflammation / immunology*
  • Macaca fascicularis
  • Macaca mulatta
  • Mice
  • Mice, Nude
  • Mice, Transgenic
  • Rats
  • Rats, Inbred Lew
  • Retina / immunology
  • Retina / pathology
  • Uveitis / immunology
  • Uveitis / pathology