Treatment choice, duration, and cost in patients with interstitial cystitis and painful bladder syndrome

Int Urogynecol J. 2011 Apr;22(4):395-400. doi: 10.1007/s00192-010-1252-8. Epub 2010 Sep 2.

Abstract

Introduction and hypothesis: In order to better understand provider treatment patterns for interstitial cystitis (IC)/painful bladder syndrome, we sought to document the therapies utilized and their associated expenditures using a national dataset.

Methods: A cohort was created by applying the ICD-9 diagnosis of IC (595.1) to INGENIX claims for the year 1999. Subjects were followed for 5 years, and patterns of care and related expenditures were evaluated.

Results: Of 553,910 adults insured in 1999, 89 subjects had a diagnosis of IC with 5-year follow-up data. All subjects were treated with oral medication(s), 26% received intravesical treatments, and 22% underwent hydrodistension. Total expenditures per subject were $2,808.

Conclusions: The majority of IC expenditures were attributable to oral medical therapy. Hydrodistension and intravesical instillations were utilized in less than 25% of patients. Hydrodistension was used more frequently among subjects with a new diagnosis; this may reflect its utilization as part of a diagnostic algorithm.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Administration, Intravesical
  • Administration, Oral
  • Adrenergic Uptake Inhibitors / economics
  • Adrenergic Uptake Inhibitors / therapeutic use
  • Adult
  • Aged
  • Amines / economics
  • Amines / therapeutic use
  • Amitriptyline / economics
  • Amitriptyline / therapeutic use
  • Anticoagulants / economics
  • Anticoagulants / therapeutic use
  • Cyclohexanecarboxylic Acids / economics
  • Cyclohexanecarboxylic Acids / therapeutic use
  • Cystitis, Interstitial / drug therapy*
  • Cystitis, Interstitial / economics
  • Female
  • Gabapentin
  • Humans
  • Middle Aged
  • Muscarinic Antagonists / economics
  • Muscarinic Antagonists / therapeutic use*
  • Narcotics / economics
  • Narcotics / therapeutic use*
  • Pentosan Sulfuric Polyester / economics
  • Pentosan Sulfuric Polyester / therapeutic use
  • Practice Patterns, Physicians'
  • Treatment Outcome
  • Young Adult
  • gamma-Aminobutyric Acid / economics
  • gamma-Aminobutyric Acid / therapeutic use

Substances

  • Adrenergic Uptake Inhibitors
  • Amines
  • Anticoagulants
  • Cyclohexanecarboxylic Acids
  • Muscarinic Antagonists
  • Narcotics
  • Amitriptyline
  • Pentosan Sulfuric Polyester
  • gamma-Aminobutyric Acid
  • Gabapentin