Chk1 suppressed cell death

Cell Div. 2010 Sep 2;5:21. doi: 10.1186/1747-1028-5-21.


The role of Chk1 in the cellular response to DNA replication stress is well established. However recent work indicates a novel role for Chk1 in the suppression of apoptosis following the disruption of DNA replication or DNA damage. This review will consider these findings in the context of known pathways of Chk1 signalling and potential applications of therapies that target Chk1.