Phosphotyrosine signaling: evolving a new cellular communication system

Cell. 2010 Sep 3;142(5):661-7. doi: 10.1016/j.cell.2010.08.023.


Tyrosine phosphorylation controls many cellular functions. Yet the three-part toolkit that regulates phosphotyrosine signaling-tyrosine kinases, phosphotyrosine phosphatases, and Src Homology 2 (SH2) domains-is a relatively new innovation. Genomic analyses reveal how this revolutionary signaling system may have originated and why it rapidly became critical to metazoans.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Choanoflagellata / genetics
  • Choanoflagellata / metabolism
  • Evolution, Molecular*
  • Phosphotyrosine / metabolism*
  • Protein-Tyrosine Kinases / metabolism
  • Signal Transduction*


  • Phosphotyrosine
  • Protein-Tyrosine Kinases