The language of histone crosstalk

Cell. 2010 Sep 3;142(5):682-5. doi: 10.1016/j.cell.2010.08.011.


It has been suggested that a specific pattern of histone posttranslational modifications and their crosstalk may constitute a code that determines transcriptional outcomes. However, recent studies indicate that histone modifications have context-dependent effects, making their interplay more like a language within the chromatin signaling pathway than a code.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Chromatin / metabolism*
  • Histone Code
  • Histones / metabolism*
  • Phosphorylation
  • Protein Processing, Post-Translational*
  • Transcription, Genetic


  • Chromatin
  • Histones