Antibiotic resistance in neonatal intensive care unit pathogens: mechanisms, clinical impact, and prevention including antibiotic stewardship

Clin Perinatol. 2010 Sep;37(3):547-63. doi: 10.1016/j.clp.2010.06.004.


Antimicrobial-resistant pathogens are of increasing concern in the neonatal intensive care unit population. A myriad of resistance mechanisms exist in microorganisms, and management can be complex because broad-spectrum antibiotics are increasingly needed. Control and prevention of antibiotic-resistant organisms (AROs) require an interdisciplinary team with continual surveillance. Judicious use of antibiotics; minimizing exposure to risk factors, when feasible; and effective hand hygiene are crucial interventions to reduce infection and transmission of AROs.

Publication types

  • Review

MeSH terms

  • Anti-Infective Agents / therapeutic use*
  • Cross Infection* / epidemiology
  • Cross Infection* / microbiology
  • Cross Infection* / prevention & control
  • Drug Resistance, Microbial*
  • Humans
  • Infant, Newborn
  • Intensive Care Units, Neonatal*
  • Risk Factors


  • Anti-Infective Agents