Changes in serum TSH and free T4 during human sleep restriction

Sleep. 2010 Aug;33(8):1115-8. doi: 10.1093/sleep/33.8.1115.


Study objectives: To examine whether recurrent sleep restriction is accompanied by changes in measures of thyroid function.

Design: Two-period crossover intervention study.

Setting: University clinical research center and sleep laboratory.

Participants: 11 healthy volunteers (5F/6M) with a mean (+/- SD) age of 39 +/- 5 y and BMI 26.5 +/- 1.5 kg/m2.

Intervention: Randomized exposure to 14 days of sedentary living with ad libitum food intake and 5.5- vs. 8.5-h overnight sleep opportunity.

Measurements and results: Serum thyroid-stimulating hormone (TSH) and free thyroxine (T4) were measured at the end of each intervention. Partial sleep restriction was accompanied by a modest but statistically significant reduction in TSH and free T4, seen mainly in the female participants of the study.

Conclusions: Compared to the well-known rise in TSH and thyroid hormone concentrations during acute sleep loss, tests obtained after 14 days of partial sleep restriction did not show a similar activation of the human thyroid axis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Circadian Rhythm / physiology
  • Female
  • Humans
  • Male
  • Recurrence
  • Reference Values
  • Sleep Deprivation / blood*
  • Thyrotropin / blood*
  • Thyroxine / blood*


  • Thyrotropin
  • Thyroxine