Recent advances in hydrogen research as a therapeutic medical gas

Free Radic Res. 2010 Sep;44(9):971-82. doi: 10.3109/10715762.2010.500328.


Recent basic and clinical research has revealed that hydrogen is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs. Therapeutic hydrogen has been applied by different delivery methods including straightforward inhalation, drinking hydrogen dissolved in water and injection with hydrogen-saturated saline. This review summarizes currently available data regarding the protective role of hydrogen, provides an outline of recent advances in research on the use of hydrogen as a therapeutic medical gas in diverse models of disease and discusses the feasibility of hydrogen as a therapeutic strategy. It is not an overstatement to say that hydrogen's impact on therapeutic and preventive medicine could be enormous in the future.

Publication types

  • Evaluation Study
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Antioxidants / therapeutic use
  • Biomedical Research / trends*
  • Chemical Industry / methods
  • Chemoprevention / methods
  • Disease Models, Animal
  • Gases / therapeutic use*
  • Humans
  • Hydrogen / chemistry
  • Hydrogen / physiology
  • Hydrogen / therapeutic use*
  • Inhibitor of Apoptosis Proteins / therapeutic use
  • Models, Biological


  • Anti-Inflammatory Agents
  • Antioxidants
  • Gases
  • Inhibitor of Apoptosis Proteins
  • Hydrogen