Role of vitamin D in cardiovascular health

Am J Cardiol. 2010 Sep 15;106(6):798-805. doi: 10.1016/j.amjcard.2010.04.042. Epub 2010 Aug 1.


Observational studies strongly associate vitamin D deficiency with a variety of cardiovascular diseases beyond defects in bone and calcium metabolism. Vitamin D has multiple mechanisms that potentially may affect cardiovascular health. Because vitamin D deficiency is common, therapies directed at the replacement of vitamin D may be beneficial. To date however, studies evaluating vitamin D supplementation are few and have not consistently shown benefit. It is possible that the lack of benefit in these studies may have arisen from suboptimal levels of vitamin D supplementation or other unknown factors. Nevertheless, the growing body of observational data and consistent findings of relatively high rates of low vitamin D serum levels warrant further well-designed studies to investigate the relation between vitamin D and cardiovascular health. In conclusion, vitamin D is now recognized as important for cardiovascular health and its deficiency as a potential risk factor for several cardiovascular disease processes.

Publication types

  • Review

MeSH terms

  • Arrhythmias, Cardiac / prevention & control
  • Bone Density Conservation Agents / metabolism
  • Bone Density Conservation Agents / therapeutic use*
  • Bone and Bones / drug effects
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / prevention & control*
  • Coronary Artery Disease / prevention & control
  • Endothelium, Vascular / drug effects
  • Evidence-Based Medicine
  • Humans
  • Myocardial Infarction / prevention & control
  • Nutritional Requirements
  • Risk Factors
  • Treatment Outcome
  • Vitamin D / metabolism
  • Vitamin D / therapeutic use*
  • Vitamin D Deficiency / complications
  • Vitamin D Deficiency / physiopathology
  • Vitamin D Deficiency / prevention & control*


  • Bone Density Conservation Agents
  • Vitamin D