Notch targets and their regulation

Curr Top Dev Biol. 2010;92:253-75. doi: 10.1016/S0070-2153(10)92008-5.

Abstract

The proteolytic cleavages elicited by activation of the Notch receptor release an intracellular fragment, Notch intracellular domain, which enters the nucleus to activate the transcription of targets. Changes in transcription are therefore a major output of this pathway. However, the Notch outputs clearly differ from cell type to cell type. In this review we discuss current understanding of Notch targets, the mechanisms involved in their transcriptional regulation, and what might underlie the activation of different sets of targets in different cell types.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Humans
  • Receptors, Notch / genetics
  • Receptors, Notch / metabolism*
  • Signal Transduction*
  • Transcription Factors / metabolism*
  • Transcription, Genetic
  • Transcriptional Activation

Substances

  • Receptors, Notch
  • Transcription Factors