Neurophysiology of dystonia: The role of inhibition

Neurobiol Dis. 2011 May;42(2):177-84. doi: 10.1016/j.nbd.2010.08.025. Epub 2010 Sep 15.


The pathophysiology of dystonia has been best studied in patients with focal hand dystonia. A loss of inhibitory function has been demonstrated at spinal, brainstem and cortical levels. Many cortical circuits seem to be involved. One consequence of the loss of inhibition is a failure of surround inhibition, and this appears to directly lead to overflow and unwanted muscle spasms. There are mild sensory abnormalities and deficits in sensorimotor integration; these also might be explained by a loss of inhibition. Increasing inhibition may be therapeutic. A possible hypothesis is that there is a genetic loss of inhibitory interneurons in dystonia and that this deficit is a substrate on which other factors can act to produce dystonia. This article is part of a Special Issue entitled "Advances in dystonia".

Publication types

  • Review

MeSH terms

  • Animals
  • Dystonic Disorders / physiopathology*
  • Humans
  • Motor Cortex / physiopathology*
  • Neural Inhibition / physiology*
  • Sensation Disorders / complications
  • Sensation Disorders / physiopathology
  • Transcranial Magnetic Stimulation