Planar cell polarity signaling, cilia and polarized ciliary beating

Curr Opin Cell Biol. 2010 Oct;22(5):597-604. doi: 10.1016/j.ceb.2010.07.011.

Abstract

Planar cell polarity signaling governs a wide array of polarized cell behaviors in animals. Recent reports now show that PCP signaling is essential for the directional beating of motile cilia. Interestingly, PCP signaling acts in a variety of ciliated cell types that use motile cilia to generate directional fluid flow in very different ways. This review will synthesize these recent papers and place them in context with previous studies of PCP signaling in polarized cellular morphogenesis and collective cell movement.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Polarity*
  • Cilia / physiology*
  • Humans
  • Signal Transduction