A near infra-red spectroscopy study of the effects of pre-frontal single and paired pulse transcranial magnetic stimulation

Richard H Thomson; Zafiris J Daskalakis; Paul B Fitzgerald

doi:10.1016/j.clinph.2010.08.003

A near infra-red spectroscopy study of the effects of pre-frontal single and paired pulse transcranial magnetic stimulation

Clin Neurophysiol. 2011 Feb;122(2):378-82. doi: 10.1016/j.clinph.2010.08.003.

Authors

Richard H Thomson¹, Zafiris J Daskalakis, Paul B Fitzgerald

Affiliation

¹ Monash Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychology, Psychiatry and Psychological Medicine, Vic., Australia.

PMID: 20817548
DOI: 10.1016/j.clinph.2010.08.003

Abstract

Objective: Concentration changes in hemoglobin following single and paired pulse (2 and 15 ms inter-stimulus interval) transcranial magnetic stimulation (TMS) was investigated using near infra-red spectroscopy (NIRS).

Methods: TMS was delivered to left pre-frontal cortex at typical intensities used in neuroscience research and concentrations of deoxyhemoglobin (Hb), oxyhemoglobin (HbO) and total hemoglobin (HbT) were measured.

Results: Significant drops in concentration of HbO and HbT were observed and while there was no effect of the different pulse types on amplitude, there was a difference in the time taken to return to baseline.

Conclusions: The changes observed imply that in pre-frontal cortex, the different TMS pulse types result in differential effects on oxygen consumption.

Significance: This study aids our understanding of the physiological effects of single and paired pulse TMS.

Publication types

Comparative Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Female
Humans
Male
Prefrontal Cortex / physiology*
Spectroscopy, Near-Infrared / methods*
Transcranial Magnetic Stimulation / methods*
Young Adult