The role of inflammation in HPV carcinogenesis

Carcinogenesis. 2010 Nov;31(11):1905-12. doi: 10.1093/carcin/bgq176. Epub 2010 Sep 5.


The role of inflammation in human papillomavirus (HPV) infection and disease is complex since it involves responses capable of preventing initial infections, clearing those ongoing as well as promoting persistence and progression of associated lesions. Avoiding the immune response has been considered a key aspect of HPV persistence which is the main factor leading to HPV-related neoplasia. HPVs have evolved different ways of targeting immune signaling pathways. Moreover, host inflammatory response may promote lesion progression and affect tumor fate by diverse mechanisms including the direct participation of inflammatory cells. In this review, we discuss the interplay between HPV oncogenic proteins and an array of inflammatory responses that ultimately may lead to cancer.

Publication types

  • Review

MeSH terms

  • Cell Transformation, Neoplastic
  • Humans
  • Inflammation / immunology*
  • Neoplasms / immunology*
  • Neoplasms / virology
  • Oncogenes / physiology*
  • Papillomaviridae / pathogenicity*
  • Papillomavirus Infections / immunology*
  • Papillomavirus Infections / pathology
  • Papillomavirus Infections / virology