We describe several results characterizing the Hubble Space Telescope from measured point spread functions by using phase-retrieval algorithms. The Cramer-Rao lower bounds show that point spread functions taken well out of focus result in smaller errors when aberrations are estimated and that, for those images, photon noise is not a limiting factor. Reconstruction experiments with both simulated and real data show that the calculation of wave-front propagation by the retrieval algorithms must be performed with a multiple-plane propagation rather than a simple fast Fourier transform to ensure the high accuracy required. Pupil reconstruction was performed and indicates a misalignment of the optical axis of a camera relay telescope relative to the main telescope. After we accounted for measured spherical aberration in the relay telescope, our estimate of the conic constant of the primary mirror of the HST was - 1.0144.