Extract of passion fruit (Passiflora edulis) seed containing high amounts of piceatannol inhibits melanogenesis and promotes collagen synthesis

J Agric Food Chem. 2010 Oct 27;58(20):11112-8. doi: 10.1021/jf102650d. Epub 2010 Sep 7.


The effect of passion fruit, the fruit of Passiflora edulis , on melanin inhibition and collagen synthesis was studied using cultured human melanoma and fibroblast cells. Passion fruit was divided into three parts, rind (PF-R), pulp (PF-P), and seed (PF-S), and each part was extracted using 80% ethanol. The concentration of polyphenols was higher in PF-S than in PF-R or PF-P. Treatment of melanoma cells with PF-S led to inhibition of melanogenesis. In addition, the production of total soluble collagen was elevated in dermal fibroblast cells cultured in the presence of PF-S. PF-R and PF-P did not yield these effects. Furthermore, the removal of polyphenols from PF-S led to the abolishment of the effects described above. We discovered that piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is present in passion fruit seeds in large amounts and that this compound is the major component responsible for the PF-S effects observed on melanogenesis and collagen synthesis.

MeSH terms

  • Cell Line, Tumor
  • Collagen / biosynthesis*
  • Fruit / chemistry
  • Humans
  • Melanins / biosynthesis*
  • Passiflora / chemistry*
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology*
  • Seeds / chemistry*
  • Stilbenes / pharmacology*


  • Melanins
  • Plant Extracts
  • Stilbenes
  • 3,3',4,5'-tetrahydroxystilbene
  • Collagen