A natural product telomerase activator as part of a health maintenance program

Rejuvenation Res. 2011 Feb;14(1):45-56. doi: 10.1089/rej.2010.1085. Epub 2010 Sep 7.


Most human cells lack sufficient telomerase to maintain telomeres, hence these genetic elements shorten with time and stress, contributing to aging and disease. In January, 2007, a commercial health maintenance program, PattonProtocol-1, was launched that included a natural product-derived telomerase activator (TA-65®, 10-50 mg daily), a comprehensive dietary supplement pack, and physician counseling/laboratory tests at baseline and every 3-6 months thereafter. We report here analysis of the first year of data focusing on the immune system. Low nanomolar levels of TA-65® moderately activated telomerase in human keratinocytes, fibroblasts, and immune cells in culture; similar plasma levels of TA-65® were achieved in pilot human pharmacokinetic studies with single 10- to 50-mg doses. The most striking in vivo effects were declines in the percent senescent cytotoxic (CD8(+)/CD28(-)) T cells (1.5, 4.4, 8.6, and 7.5% at 3, 6, 9, and 12 months, respectively; p = not significant [N.S.], 0.018, 0.0024, 0.0062) and natural killer cells at 6 and 12 months (p = 0.028 and 0.00013, respectively). Most of these decreases were seen in cytomegalovirus (CMV) seropositive subjects. In a subset of subjects, the distribution of telomere lengths in leukocytes at baseline and 12 months was measured. Although mean telomere length did not increase, there was a significant reduction in the percent short (<4 kbp) telomeres (p = 0.037). No adverse events were attributed to PattonProtocol-1. We conclude that the protocol lengthens critically short telomeres and remodels the relative proportions of circulating leukocytes of CMV(+) subjects toward the more "youthful" profile of CMV(-) subjects. Controlled randomized trials are planned to assess TA-65®-specific effects in humans.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Products / pharmacology*
  • Cell Count
  • Cells, Cultured
  • Cytomegalovirus / drug effects
  • Enzyme Activators / pharmacology*
  • Female
  • Fetus / cytology
  • Fibroblasts / drug effects
  • Fibroblasts / enzymology
  • Health*
  • Humans
  • Immune System / drug effects
  • Infant, Newborn
  • Keratinocytes / drug effects
  • Keratinocytes / enzymology
  • Male
  • Middle Aged
  • Telomerase / metabolism*
  • Telomere / metabolism
  • Time Factors


  • Biological Products
  • Enzyme Activators
  • Telomerase