Effects of thyroid hormone on A1C and glycated albumin levels in nondiabetic subjects with overt hypothyroidism

Diabetes Care. 2010 Dec;33(12):2546-8. doi: 10.2337/dc10-0988. Epub 2010 Sep 7.

Abstract

Objective: We aimed to determine the effects of thyroid hormone on A1C and glycated albumin (GA) in nondiabetic patients with overt hypothyroidism.

Research design and methods: A1C levels were measured in 45 nondiabetic patients with overt hypothyroidism and 180 euthyroid control subjects. A1C, GA, fasting blood glucose (FBG), 1,5-anhydroglucitol, and erythrocyte indexes were determined in 30 nondiabetic patients with overt hypothyroidism before and after thyroid hormone replacement.

Results: A1C levels were higher in patients with hypothyroidism compared with control subjects. A1C levels were decreased by thyroid hormone replacement. Thyroid hormone replacement increased serum erythropoietin, reticulocyte count, and mean corpuscular hemoglobin (MCH). The change in A1C level was significantly correlated with the change in reticulocyte count or MCH. Thyroid hormone replacement decreased serum levels of albumin and GA. However, FBG and 1,5-anhydroglucitol levels were not altered.

Conclusions: Levels of A1C and GA are spuriously high in nondiabetic patients with overt hypothyroidism.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cross-Sectional Studies
  • Erythrocyte Indices / drug effects
  • Erythropoietin / blood
  • Female
  • Glycated Hemoglobin A / metabolism*
  • Humans
  • Hypothyroidism / blood
  • Hypothyroidism / drug therapy*
  • Hypothyroidism / metabolism*
  • Hypothyroidism / radiotherapy
  • Iodine Radioisotopes / therapeutic use
  • Male
  • Middle Aged
  • Reticulocyte Count
  • Serum Albumin / metabolism
  • Thyroid Hormones / therapeutic use*

Substances

  • Glycated Hemoglobin A
  • Iodine Radioisotopes
  • Serum Albumin
  • Thyroid Hormones
  • Erythropoietin