Role of NF-kappaB in the anti-inflammatory effects of tocotrienols

J Am Coll Nutr. 2010 Jun;29(3 Suppl):334S-339S. doi: 10.1080/07315724.2010.10719848.


The NF-kappaB family of transcription factors regulates genes that are critical for inflammation and immunity. In most cells, NF-kappaB function is induced upon activation of cells by various stimuli. However, constitutive NF-kappaB activity is an equally important aspect of NF-kappaB function that is particularly relevant to chronic inflammation and cancer. Here, we provide a brief overview of NF-kappaB biology and discuss the role of NF-kappaB in mediating the anti-inflammatory effects of tocotrienols The NF-kappaB family of transcription factors is a central player in the regulation of inflammation and immune responses. Consequently, NF-kappaB dysregulation has been implicated in diverse human pathologies ranging from autoimmune diseases to cancers. Additionally, there is considerable interest in the contribution of NF-kappaB-mediated chronic inflammation in aging. Because NF-kappaB-dependent gene regulation is important in virtually all mammalian cell types, it is critical to keep in mind some basic features of its functions when considering interventional therapeutics.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Aging / physiology
  • Anti-Inflammatory Agents / therapeutic use*
  • Autoimmune Diseases / metabolism
  • Gene Expression Regulation
  • Humans
  • Inflammation / drug therapy
  • Inflammation / physiopathology*
  • NF-kappa B / metabolism*
  • Neoplasms / metabolism
  • Tocotrienols / therapeutic use*


  • Anti-Inflammatory Agents
  • NF-kappa B
  • Tocotrienols