Mismatch repair in mammalian cells

Bioessays. 1990 Oct;12(10):473-7. doi: 10.1002/bies.950121004.


A vital process in maintaining a low genetic error rate is the removal of mismatched bases in DNA. The importance of this process in E. coli is demonstrated by the 100-1000 fold increase in mutation frequency observed in cells deficient in this repair system. Mismatches can arise as a consequence of recombination, errors in replication and as a result of spontaneous chemical deamination, the latter process resulting in an estimated twelve T:G mismatches per genome per day in mammalian cells. Recent studies, discussed here, provide evidence for the existence of specific mismatch repair systems in mammalian and human cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA Repair*
  • Humans
  • Mammals / genetics