Towards patient-based cancer therapeutics

Nat Biotechnol. 2010 Sep;28(9):904-6. doi: 10.1038/nbt0910-904.


A new approach to the discovery of cancer therapeutics is emerging that begins with the cancer patient. Genomic analysis of primary tumors is providing an unprecedented molecular characterization of the disease. The next step requires relating the genetic features of cancers to acquired gene and pathway dependencies and identifying small-molecule therapeutics that target them.

MeSH terms

  • Animals
  • Antineoplastic Agents / therapeutic use*
  • Disease Models, Animal
  • Drug Discovery
  • Gene Regulatory Networks / genetics
  • Humans
  • Mice
  • National Cancer Institute (U.S.)
  • Neoplasm Proteins / metabolism
  • Neoplasms / drug therapy*
  • Neoplasms / genetics
  • Precision Medicine*
  • RNA, Small Interfering / metabolism
  • United States


  • Antineoplastic Agents
  • Neoplasm Proteins
  • RNA, Small Interfering