[Biological properties of two newly established cell lines (RMUG-S, RMUG-L) from a human ovarian mucinous cystadenocarcinoma]

Hum Cell. 1990 Mar;3(1):52-6.
[Article in Japanese]


Two morphological different cell lines (RMUG-S and RMUG-L) have been established from a human ovarian mucinous cystadenocarcinoma. CA-125 and CEA were demonstrated in the patient's serum. PAS, Alcian blue and mucicarmine positive substances were observed in the original tumor and two cultured cells. The modal chromosomal numbers of RMUG-S and RMUG-L were stable in the hypodiploid and hyper-triploid ranges, respectively. Radioimmunoassay and immunocytochemical staining revealed that RMUG-S and RMUG-L mainly produced CA-125 and CEA, respectively. In CBA nude mouse, RMUG-S and RMUG-L cells mainly produced poorly-differentiated adenocarcinoma, but in mucinous cystadenocarcinoma was detected in part of the RMUG-L tumor.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Antigens, Tumor-Associated, Carbohydrate / analysis
  • Biomarkers, Tumor / analysis
  • Carcinoembryonic Antigen / analysis
  • Cystadenocarcinoma / immunology
  • Cystadenocarcinoma / pathology*
  • DNA, Neoplasm / analysis
  • Female
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Middle Aged
  • Neoplasm Transplantation
  • Ovarian Neoplasms / immunology
  • Ovarian Neoplasms / pathology*
  • Tumor Cells, Cultured*


  • Antigens, Tumor-Associated, Carbohydrate
  • Biomarkers, Tumor
  • Carcinoembryonic Antigen
  • DNA, Neoplasm