Efficacy of a single dose hepatitis B depot vaccine

Vaccine. 2010 Oct 18;28(44):7143-5. doi: 10.1016/j.vaccine.2010.08.084. Epub 2010 Sep 9.


A single dose formulation of a novel hepatitis B vaccine, consisting of an adjuvant emulsion of liposomes in oil was produced at a manufacturing scale and delivered to rabbits. This single dose vaccine generated a significantly higher antibody response than two doses of an alum-adjuvanted control vaccine in the short term, and was as effective as three doses of the control vaccine in the long term.

Publication types

  • Comparative Study

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Animals
  • Dose-Response Relationship, Immunologic
  • Drug Evaluation, Preclinical
  • Female
  • Hepatitis B / prevention & control
  • Hepatitis B Antibodies / blood
  • Hepatitis B Vaccines / administration & dosage*
  • Liposomes / administration & dosage*
  • Rabbits


  • Adjuvants, Immunologic
  • Hepatitis B Antibodies
  • Hepatitis B Vaccines
  • Liposomes